Pacific Neuroscience Institute Sets New Standard of Excellence in Minimally Invasive Keyhole Surgery
SANTA MONICA – In a groundbreaking 13-year study, Pacific Neuroscience Institute neurosurgical and otolaryngology surgical teams demonstrated outstanding outcomes with minimally invasive keyhole surgery for the most common primary brain tumor, in the largest such cohort published to date.
The study, conducted in collaboration with Providence Saint John’s Health Center, was published in the July 28 issue of PLOS ONE. Findings demonstrate a combination of excellent tumor removal rates, lower surgical complication rates and a higher rate of functional preservation, compared to prior publications of intracranial meningioma surgery using more traditional approaches.
“Patients coming to us with brain tumors are understandably worried about their diagnoses and clinical outcomes,” said neurosurgeon Daniel Kelly, M.D., PNI director and senior author of the study. “Keyhole surgery aims to limit brain exposure and manipulation, using smaller strategically placed openings without the use of brain retractors and facilitated by gravity assistance and endoscopy. These techniques, along with improved neuro-anesthesia and our growing experience, benefit our patients by allowing, in most cases, a faster recovery, shorter hospital stay and rapid return to daily activities.”
About Meningiomas
Meningiomas, the most common primary brain tumor, are non-cancerous brain tumors estimated to be diagnosed in approximately 34,000 people in the United States each year. Surgery for meningiomas has evolved over the last 20 years from traditional larger open craniotomies to an increase in smaller, minimally invasive approaches, including through the natural openings of the nostrils (endonasal), through an eyebrow incision (supraorbital) and other small incisions often with the assistance of a high-definition endoscope (flexible microsurgical telescope). PNI’s surgical team has helped lead this evolution in keyhole surgery for all brain and skull base tumors, with an overarching goal of maximal safe tumor removal and preservation of neurological function.
Study Results
From an overall cohort of 329 patients with meningiomas treated from 2008-21, the study focused on 193 (59%) who underwent 213 keyhole operations. Keyhole approaches included endoscopic endonasal, supraorbital eyebrow, mini-pterional, retromastoid, supracerebellar and transfalcine.
Compared to prior publications of meningioma surgery using more traditional, larger approaches, there were lower rates of permanent neurological deficits (6%), cerebrospinal fluid leaks (1%) and meningitis (1%). Notably, 94% of patients were discharged to home, and no patients sustained post-operative deep vein thrombosis, pulmonary emboli or myocardial infarction. There were no deaths within 30 days of surgery. Hospital length-of-stay also was considerably shorter (median three days) compared to most prior reports, and decreased to two days in the last two years of the study.
“Although most meningiomas are slow-growing benign tumors, they often become adherent to blood vessels, cranial nerves, and can invade the skull base, said neurosurgeon Garni Barkhoudaian, M.D., chief of the radiosurgery program and co-author of the study. “Consequently, aiming for maximal safe removal is critical to the keyhole concept because attempting complete removal in some locations can come at a high risk of major complications.
“Here at PNI, we strive to avoid such complications while still achieving excellent tumor removal rates. Fortunately, most meningiomas that cannot be removed completely can be observed over time or treated effectively and safely with focused radiation or radiosurgery.”
The article is published in PLOS ONE.
About Providence Southern California
Providence Southern California is Southern California’s largest health system with 11 hospitals, more than 100 clinics, outpatient centers, TrinityCare Hospice and its TrinityKids Care pediatric hospice, Providence High School, home health care services, eight wellness centers, telehealth and numerous physician groups in its Southern California Region. Providence is committed to an enduring mission of outreach to the poor and vulnerable, and last year contributed $608 million in services, programs and charity care to those in need.
About Pacific Neuroscience Institute
Pacific Neuroscience Institute (PNI) is devoted to the comprehensive care of patients with a wide spectrum of neurological and cranial disorders. Dedicated teams of specialists, state-of-the-art facilities, and the use of leading-edge treatment along with our collaborative approach ensure that each patient receives the attention they require for successful treatment and recovery. PNI’s specialty clinics are located at award winning hospitals Providence Saint John’s Health Center in Santa Monica and Providence Little Company of Mary Medical Center in Torrance, California. PacificNeuro.org
