This week, the 40th annual Society for Immunotherapy of Cancer (SITC) meeting gets underway in National Harbor, Maryland. Researchers, physicians, clinicians and students from around the world will present their cancer immunotherapy research in oral and poster abstract presentations.
We’re thrilled to announce that three researchers from Providence Cancer Institute have been selected for the 2025 Champion of SITC Award: Bernard Fox, Ph.D., William Redmond, Ph.D., and Walter Urba, M.D., Ph.D.
This coveted award honors individuals who have made a significant contribution to SITC’s mission by helping the organization reach its goals.
Also, on Thursday, Nov. 6, the SITC 2025 Workshop will explore the recent advances in cancer immunology and AI, and how these fields can converge to effectively address current hurdles in IO. Carlo Bifulco, M.D., medical director, Cancer Genomics and Precision Oncology at Providence Cancer Institute, is a program organizer. Find out more about the workshop and register here.
Read on to find abstracts by Providence Cancer Institute researchers and sessions where our researchers are presenting:
Concurrent Session 207c: The Dark Genome: Making Cryptic Epitopes Actionable
Nov. 8, 3:30-5:10 p.m. ET | Gaylord National Resort and Convention Center - Ballroom Level - Cherry Blossom Level
- Introduction: Bernard A. Fox, Ph.D.
- Proteasomal Cargo Biologic in Prime/Boost with PD-1 Blockade: Rom S. Leidner, M.D.
Poster Presentations
Category: Biomarkers, Immune Monitoring and Novel Technologies
Abstract 163: Unveiling the Non-Canonical Dark Immunopeptidome of Head and Neck Squamous Cell Carcinoma (HNSCC) and Non-Small Cell Lung Cancer (NSCLC) using Mass Spectrometry and WatchMaker Total RNA-Seq
Presenting Author: Ryan Meng, Providence Cancer Institute
Authors: Ryan Meng, Tarsem Moudgil, Noriko Iwamoto, Yuriko Minegishi, Yoshinobu Koguchi, Traci Hilton, Blake Tsu, Stephanie Kairs, Christopher Barnes, Venkatesh Rajamanickam, Tanisha Christie, Eric Tran, William Redmond, Carlo Bifulco, Alexa Dowdell, Shawn Jensen, Jianguo Huang, Christopher Paustian, Ashish Patel, Hong-Ming Hu, Bryan Bell, Walter Urba, Koji Ueda, Takashi Shimada, Brian Piening, Rom Leidner, Bernard Fox
Presentation Type: Poster
Abstract 192: Development of the Proteogenomic Antibody Repertoire Assay for Anti-tumor Antibody Discovery
Authors: Gaurav Shrestha, Noriko Iwamoto, Lauren Hamilton, Tanisha Christie, P. Dominick Sanders, Brian Piening, Bernard Fox, William Redmond, Jordan Krull, Qin Ma, Mitch Phelps, Zhiwei Hu, Zihai Li, Mark Rubinstein, Takashi Shimada, Yoshinobu Koguchi Presentation Type: Poster
Abstract 176: Spatial andseromic profiling of tumor infiltrating B-cell subtypes and autoantibody production in oral cancers
Authors: Dennis Nijenhuis, Sonja Ganzevles, Mila Broekhuizen, Irene Nauta, Traci Hilton, Bernard Fox, Elisabeth Bloemena, Laura Peferoen, C. René Leemans, Ruud Brakenhoff, Rieneke Van de Ven
Presentation Type: Poster
Top 150 🎗
Abstract 189: Baseline NKT cells as a potential predictive biomarker for treatment with an anchored IL-12 drug conjugate in patients with solid tumors
Authors: Kanika Jain, Lisa Sturla, Jong Chul Park, Brendan Curti, Marcus Butler, Gail Iodice, Joseph Elassal, James Gulley, Jeffrey Schlom, Howard Kaufman, John Kirkwood, Sailaja Battula Presentation Type: Oral
Category: Immune Cell Types and Biology
Abstract 832: Integrative multi-omics analysis reveals enrichment of exhausted CD8⁺ and CD4⁺CD8⁺ T cells in the renal cell carcinoma tumor microenvironment
Presenting Author: William Redmond, Providence Cancer Institute Authors: Mahnaz Janghorban, Yoshinobu Koguchi, Noah Simons, Duncan Hindmarch, Wesley Rosales, Venkatesh Rajamanickam, Tanisha Christie, William Miller, Iliana Gonzalez, Melissa Kasiewicz, Lakhvir Kaur, Brendan Curti, Tarsem Mougdil, Laura Wehr, Niranjan Yanamandra, Johanna Kaufmann, Thomas Duhen, William Redmond
Presentation type: Poster
Category: Combination Therapies
Abstract 636: Addition of GITR Agonist to a Dark Matter Cancer Vaccine and anti-PD-1 Increases Regulatory T cell Numbers Without Appearing to Impact Therapeutic Efficacy Presenting Author: Guo Hui Gan – Providence Cancer Institute
Authors: Rom Leidner, Guo Hui Gan, Christopher Paustian, Shawn Jensen, Yoshinobu Koguchi, Tarsem Moudgil, Noah Simons, Venkatesh Rajamanickam, Ryan Meng, Marcus Couey, Matthew Taylor, Lakhvir Kaur, Brady Bernard, Tanisha Christie, Annie Long, Patrick Rethwisch, Elizabeth Gould, William Redmond, Robert Hermann, Carlo Bifulco, Traci Hilton, Hong-Ming Hu, Brian Piening, Walter Urba, Bryan Bell, Bernard Fox
Presentation Type: Poster
Top 150 🎗 - Young Investigator Award
Abstract 676: Lymphatic-Sparing Immunoradiotherapy Reprograms Migratory Dendritic Cells to Drive Tumor Rejection via the Sentinel Lymph Node
Authors: Robert Saddawi-Konefka, Riyam Al Msari, Shiqi Tang, Chad Philips, Sayed Sadat, Lauren Clubb, Robert Saddawi-Konefka, Santiago Fassardi, Riley Jones, Ida Saddawi-Konefka, Farhoud Faraji, Shiruyeh Schokrpur, Bryan Yung, Michael Allevato, Kelsey Decker, Chanond Nasamran, Daisy Chilin-Fuentes, Sara Rosenthal, Shawn Jensen, Bernard Fox, Bryan Bell, Silvio Gutkind, Andrew Sharabi, Joseph Califano
Presentation Type: Oral
Primary Category: Clinical Trials In Progress
Abstract 592: Phase I Study: CD39⁺CD103⁺CD8⁺ Selected TIL Therapy (AGX-148) Demonstrates Clinical Activity in Patients with Metastatic Solid Tumors
Presenting Author: Colin Thalhofer – AgonOx, Inc.
Authors: Colin Thalhofer, Ryan Montler, Elaine Ballinger, Jessica Cross, Nick Morris, Jake Moses, Nelson SanJuan, Eric Tran, Christopher Fountain, Shannon Erickson, Roxanne Payne, Rom Leidner, Brendan Curti, Andrew Weinberg
Presentation Type: Poster
Primary Category: Machine Learning, Artificial Intelligence & Computational Modeling
Abstract 1118: Deep learning serial CT imaging biomarker for predicting overall survival: A real-world validation in multiple indications of advanced solid tumors treated with immune checkpoint inhibitors.
Authors: Chiharu Sako, Taly Schmidt, Arpan Patel, Dwight Owen, Ronan Kelly, Roshan Vincent, Beatriz Lourenco, Jason Chan, Ross McCall, Christine Kassis, Roshanthi Weerasinghe, Bryan Bell, Gregory Vidal, George Simon, Ravi Parikh, Petr Jordan, Brendan Curti
Presentation Type: Poster
To get more information about these abstracts and others, visit the SITC 2025 site.
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